吉坤美教授团队尘螨过敏原研究成果
RESEARCH ACHIEVEMENT
1. Cai ZL, Liu S, Li WY, Zhou ZW, Hu WZ, Chen JJ, Ji K. Kunmei Ji, Identification of an immunodominant IgE epitope of Der f 40, a novel allergen of Dermatophagoides farina. World Allergy Organ J. 2023 Aug 1;16(8):100804.
2. Li WY, Cai ZL, Zhang BP, Chen JJ, Ji K. Identification of an immunodominant IgE epitope of Der p 39, a novel allergen of Dermatophagoides pteronyssinus.World Allergy Organ J. 2022 May 6;15(5):100651.
3. Chen J, Cai Z, Fan D, Hu J, Hou Y, He Y, Zhang Z, Zhao Z, Gao P, Hu W, Sun J, Li J, Ji K.Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39. World Allergy Organ J. 2021 Sep 28;14(10):100590.
4. Cai ZL, Zhang Z, Luo WL, Hou YB, He YS, Chen JJ, Ji K. Identification of immunodominant IgE epitopes of the major house dust mite allergen Der f 24. Int J Mol Med. 2019 Nov;44(5):1888-1898.
5. He Y, Dou C, Su Y, Chen J, Zhang Z, Zhao Z, Chen J, Ji K. Identification of Der f 23 as a new major allergen of Dermatophagoides farinae. Mol Med Rep. 2019 Aug;20(2):1270-1278.
6. Zhang Z, Cai Z, Hou Y, Hu J, He Y, Chen J, Ji K. Enhanced sensitivity of capture IgE‑ELISA based on a recombinant Der f 1/2 fusion protein for the detection of IgE antibodies targeting house dust mite allergens.Mol Med Rep. 2019 May;19(5):3497-3504.
7. Cai ZL, Chen JJ, Zhang Z, Hou YB, He YS, Sun JL, Ji K. Identifcation of immunodominant IgE binding epitopes of Der p 24, a major allergen of Dermatophagoides pteronyssinus. Clin Transl Allergy. 2019 May 23;9:28.
8. Chan TF, Ji KM, Yim AK, Liu XY, Zhou JW, Li RQ, Yang KY, Li J, Li M, Law PT, Wu YL, Cai ZL, Qin H, Bao Y, Leung RK, Ng PK, Zou J, Zhong XJ, Ran PX, Zhong NS, Liu ZG, Tsui SK. The draft genome, transcriptome, and microbiome of Dermatophagoides farinae reveal a broad spectrum of dust mite allergens. J Allergy Clin Immunol. 2015 Feb;135(2):539-48.
9. Zhan ZK, Ji KM, Liu XY, Liu ZG, Li M, Chen JJ, Li JN, Qiu S. Monoclonal antibodies against recombinant Der f 3 reveal localization of Der f 3 in the gut and faecal pellets of Dermatophagoides farinae.Exp Appl Acarol. 2010 Sep;52(1):63-71.
10. Liu Z, Bai Y, Ji K, Liu X, Cai C, Yu H, Li M, Bao Y, Lian Y, Gao B. Detection of Dermatophagoides Farinae in the Dust of Air-conditioning filters. Int Arch Allergy Immunol. 2007;144(1):85-90.
11.解析了尘螨过敏原Derf23部分晶体结构5ZJL。(https://www.rcsb.org/structure/5ZJL)2018.5.23
12.发现粉尘螨第24组过敏原Der f24并获得WHO/IUIS命名。(http://www.allergen.org/viewallergen.php?aid=772)2013.4.10
13.发现屋尘螨第24组过敏原Der p24并获得WHO/IUIS命名。(http://www.allergen.org/viewallergen.php?aid=855)2015.12.7
14.发现粉尘螨第23组过敏原Der f23并获得WHO/IUIS命名。(http://www.allergen.org/viewallergen.php?aid=934)2018.5.4
15. 发现粉尘螨第39组过敏原Der f39并获得WHO/IUIS命名。(http://www.allergen.org/viewallergen.php?aid=957)2019.5.1
16. 发现粉尘螨第37组过敏原Der f37并获得WHO/IUIS命名。(http://www.allergen.org/viewallergen.php?aid=960)2019.5.27
17. 发现屋尘螨第39组过敏原Der p39并获得WHO/IUIS命名。(http://www.allergen.org/viewallergen.php?aid=1070)2021.8.3
18. 发现粉尘螨第40组过敏原Der f40并获得WHO/IUIS命名。(http://www.allergen.org/viewallergen.php?aid=1085)2022.2.10
19. 发现屋尘螨第40组过敏原Der p40并获得WHO/IUIS命名。(http://www.allergen.org/viewallergen.php?aid=1086)2022.2.9
20. 发现三个过敏原IgE B细胞表位 :IEDB Reference ID 1035807(Derf24)、ID 1035090(Derp24)and ID 1040690(Derp39)。
21. 解析了粉尘螨基因组达到染色体级别,数据库公开发表(BioProject ID PRJNA512594; accession no .SDOV00000000)。
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